Antibacterial properties of BO-2727, a new carbapenem antibiotic
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Antibacterial properties of BO-2727, a new carbapenem antibiotic.
BO-2727 is a new injectable carbapenem antibiotic with broad-spectrum, potent antibacterial activity. The in-vitro and in-vivo antibacterial activities of BO-2727 were compared with those of meropenem, imipenem and biapenem. BO-2727 was four- to eight-fold more active in vitro than meropenem, imipenem and biapenem against methicillin-resistant Staphylococcus aureus, inhibiting more than 90% of ...
متن کاملIn vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity.
BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more active than imipenem and meropenem. BO-2727's antipseudomonal activity and its br...
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l R. W. Shideler, Ph.D. thesis, University of Texas, Austin, 1955; W. D. Brown, Ph.D. thesis, University of Texas, Austin, 1955. 2 M. K. Young, H. K. Berry, E. Beerstecher, Jr., and J. S. Berry, University of Texas Publication No. 5109 ("Biochemial Institute Studies," Vol. 4 [Austin: University of Texas, 19511), p .189. 3L. Bellak, Dementia Praecox (New York: Grune & Stratton, 1948), p. 27. 4R....
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1997
ISSN: 1460-2091
DOI: 10.1093/jac/40.2.195